In line with the observation in scrapie-infected hamsters, the levels of two ER-chaperone members, Grp78 and PDI, were markedly increased in cells expressing PrP-KEDL and PrP-PG15, whereas that in cells expressing wild-type PrP remained unchanged compared with the mock (Fig. 3B and C). The gene discussed is HSPA5; the disease is scrapie.