Smoking during pregnancy was a significant risk factor for obesity (OR 2.22, 95% CI, 1.13–2.83), overweight (OR 1.79, 95% CI 1.13–2.83), and highest quintile of CRP (OR 1.63, 95% CI, 1.05–2.51) among NHW (Table 5). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.