Another interesting study [90] showed that the differentiation of tumor stem-like cells into endothelial cells might be mediated initially by the Notch pathway for the differentiation in endothelial progenitor cells and subsequently by the vascular-endothelium-growth-factor- (VEGF-) signaling pathway, selectively affecting the differentiation of endothelial progenitors to tumor-derived endothelial cells. The gene discussed is VEGFA; the disease is neoplasm.