Although PPARγ/RXR heterodimers promote transcriptional activity of PPARγ [16], RXR-selective ligand LG100268 and CDDO combination was not sufficient for RARβ2 induction, suggesting that RARβ2 gene induction is not due to ligand-induced RXR activation in APL cells [93]. This evidence concerns the gene PPARG and acute promyelocytic leukemia.