In fact, it has been demonstrated that HDAC inhibitors (HDACI) such as trichostatin A (TSA), sodium phenylbutyrate (PB), and suberoylanilide hydroxamic acid (SAHA) can augment the cell growth inhibition induced by ATRA, and that ATRA combined with SAHA increased survival and induced remissions in APL transgenic mice harboring the PLZF-RARα translocation [78]. This evidence concerns the gene RARA and acute promyelocytic leukemia.