ITGAM and acute promyelocytic leukemia: Whereas CDDO alone failed to induce maturation of APL cells, the combination of CDDO with ATRA induced ATRA sensitive- and resistant-APL cells to differentiate into mature granulocytes with striking increase in Nitro Blue Tetrazolium (NBT) reduction positive and CD11b-positive cells above effects elicited by single agent ATRA [93].