IGKV1D-22 and neoplasm: While other members of this family, such as S100A4 [28, 29], S100A7 [30] and S100A13 [31], have been shown to participate under similar conditions, this discussion focuses on S100A8/A9's role in tumorigenesis by reviewing the effects of S100A8/A9 on tumor cells or vascular endothelial cells.