We recently completed a Phase II clinical trial of neoadjuvant bevacizumab and radiation therapy for patients with resectable soft tissue sarcomas.36 Twenty patients with intermediate- or high-grade soft tissue sarcomas of ≥5 cm in size received bevacizumab (an anti-VEGF-A antibody) for 2 weeks followed by 6 weeks of bevacizumab combined with radiation therapy (50 Gy). Here, VEGFA is linked to soft tissue sarcoma.