STAT3 and cancer: Although IL6 is a well characterized inflammatory target gene for TNF-α, and bleomycin-induced fibrosis is ameliorated in Tnfr−/− mice (Ortiz et al, 1998), B cell infiltrates also fuel IL-6-mediated and Stat3-dependent cancer growth following the release of lymphotoxin (LT) (Ammirante et al, 2010).