STAT1 and pulmonary fibrosis: To mimic the development of human inflammation-associated lung fibrosis in mice, we trans-nasally administered bleomycin to gender-matched mice (8–12 weeks of age) harbouring gp130 mutations that bias intracellular signalling either towards the Stat1/3 or Erk1/2 signalling pathways in gp130757F mice or gp130ΔStat mice, respectively (Tebbutt et al, 2002) (Supporting Information Fig S1).