Of these antigens, four antigens, KP-OVA-25 (TBL2), KP-OVA-35 (TNP1), KP-OVA-68 (C16orf42) and KP-OVA-73 (S100A4) reacted with 20%, 30%, 15%, and 15% ovarian cancer sera, respectively, and not with sera from normal individuals. The gene discussed is S100A4; the disease is ovarian carcinoma.