MAPT and Alzheimer disease: Alzheimer's disease (AD) is the seventh leading cause of all deaths in the United States, it is a progressive neurodegenerative disorder characterized by accumulation of amyloid-β β peptides in extracellular senile plaques intra-cellular neurofibrillary tangles (NFTs) formation resulting from hyper-phosphorylated microtubule-associated protein tau resulting in loss of neurons and consequent progressive dementia [47-49].