Intriguingly, despite reports of additional proteins including RIP1 being associated with either the CD95 or TRAIL DISC (Harper et al., 2001; reviewed in Peter and Krammer, 2003), in the hematopoetic tumor cell lines tested here, only the core components, TRAIL-Rs, FADD, and DED-only proteins (caspase-8/caspase-10 and c-FLIP), were consistently identified as bona fide DISC components. Here, CASP8 is linked to neoplasm.