BIRC3 and hepatocellular carcinoma: Of the 35 recurrent HCC samples, we found that the transcriptional and protein expressions of cyclin B1, Sec62, and Birc3 in the PBMCs were significantly higher than those in the non-recurrent and normal samples (p < 0.001, p < 0.001, and p < 0.001, respectively, Figure 2A-C).