Researchers have located “hotspot” regions of the genome at or near sequences with the potential to form non-B DNA structures, including the region in the promoter of the human c-MYC gene capable of forming triplex or G-quadruplex DNA that overlaps with one of the major breakpoint hotspots in c-MYC-induced lymphomas and leukemias[12,13]. The gene discussed is MYC; the disease is lymphoma.