Colon tumors in Figure5 in advanced clinical stages, UICC Stage III and IV (Dukes C and D) express significantly higher U2AF65 in the cytoplasm and overall than did tumors at early stages (mean value of U2AF65 tumor cytoplasm UICC Stage I and II expression = 0.349 vs. UICC Stage III and IV = 0.491; p = 0.024 [Mann-Whitney U-Test, Additional file5]). Here, U2AF2 is linked to colonic neoplasm.