We found that vagus nerve function was decreased after 2K1C surgery (i.e. at 4, 8 and 20 weeks of age); expression of α7nAChR was downregulated in aorta (from 4 weeks) and kidney (from 8 weeks), and serum TNF-α was increased in 2K1C hypertension. Here, CHRNA7 is linked to hypertensive disorder.