In contrast to many IL-1 superfamily cytokines (e.g., IL-1β and IL-18) which can have negative roles in cardiac diseases and ventricular remodeling [11], IL-33 has been demonstrated to have a potent protective role in various experimental CHF studies through inhibition of the nuclear factor kappa B (NF-κB) cascade and reduction of oxidative stress [8,12]. The gene discussed is IL1B; the disease is congestive heart failure.