In the present study we focused on CN-AML subsets well characterized for NPM1 and FLT3 status and restricted our analysis to 4 miRNAs known to be involved in normal granulocytic and/or monocytic differentiation (miR-424, miR-155, miR-223, miR-17-5p) [5]. This evidence concerns the gene NPM1 and acute myeloid leukemia.