In this review, we summarized that: (1) The source of CAFs and morphology, and the relation between heterogenicity and the malignant phenotype conversion of CAFs with time-space change; (2) The current research status and question of clinical application on CAFs; (3) The relation of CAFs and invasion and metastasis of lung cancer; (4) CAFs in the prognosis and treatment of lung cancer. This evidence concerns the gene TBX1 and lung carcinoma.