High doses of MSG injected in rodents during the neonatal period lead to the development of glucose intolerance, insulin resistance[21], and obesity[5] along with adipose tissue hypertrophy, hyperinsulinemia, hyperglycemia, hyperleptinemia, and decreased insulin stimulated glucose transport in adipocytes and muscle[22-24]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.