Interestingly, when comparing allelic distribution in our cohort with figures from the Swiss Hepatitis C cohort [24], ABCB11 c.1331 T > C is equally skewed towards an overrepresentation of the [C] allele among British patients with non-alcoholic fatty liver disease in the study by Iwata et al., pointing towards a potential role of ABCB11 via its impact on lipid metabolism rather than viral replication. Here, ABCB11 is linked to hepatitis C virus infection.