To validate and extend previous results concerning possible associations of the common polymorphism c.1331 T > C in the bile salt export pump with HCV infection and fibrosis progression, we analysed its genotype distribution in a larger cohort of 649 patients with chronic HCV infection, in 444 of whom liver fibrosis was staged non-invasively by transient liver elastography. The gene discussed is ABCB11; the disease is Hepatic fibrosis.