An increase in the cleavage of caspase-3 (including cleaved caspase-3), caspase-8 (including cleaved caspase-8) and caspase-9 (including cleaved caspase-9) was observed (Figure3A), Bax/Bcl2 ration was significantly increased (Figure3B), and the cytochrome C was increased in cytosol extract (Figure3C) in HCT116 and HT-29 colon cancer cells. Here, CASP8 is linked to colonic neoplasm.