The incidences of patients who reported AEs that are known to be associated with acetylcholinesterase inhibitors were: decreased weight (11.2%), weight loss ≥ 7% (11.1%), diarrhea (4.3%), nausea (3.5%), syncope (3.1%), vomiting (2.7%), anorexia (2.4%), bradycardia (1.2%), and gastrointestinal (GI) bleeding (0.8%, including the following terms: GI hemorrhage, hematemesis, hematochezia, melena, rectal bleeding, and upper GI hemorrhage). The gene discussed is ACHE; the disease is Gastrointestinal hemorrhage.