In conclusion, our study identified up-regulation of annexin II and S100A6 in gastric cancer, including an assessment of annexin II and S100A6 expressions in gastric cancer tissues and noncancerous gastric tissues, suggesting that overexpression of annexin II and S100A6 are common features that may play an important role in the progression and metastasis of gastric cancer. The gene discussed is S100A6; the disease is gastric cancer.