Statistical analysis showed that depth of invasion (P = 0.029), lymph node metastasis (P = 0.025), distant metastasis (P = 0.016), TNM stage (P = 0.021), expression of annexin II (P = 0.027) and expression of S100A6 (P = 0.011) were independent prognostic factors in patients with gastric carcinoma. The gene discussed is S100A6; the disease is gastric carcinoma.