Previous reviews have summarized that TORC2/mTORC2 is a mediator of actin cytoskeleton organization and cell polarization, and is known to control cytoskeleton regulators such as Rho1 GDP–GTP exchange protein 2 (Rom2) and the protein kinase A/G/C (AGC) Ypk2 in yeast, and P-Rex1 mediated Rac signaling in cancer cells [20]. The gene discussed is CRTC2; the disease is cancer.