AKT1 and non-small cell lung carcinoma: Among these recent studies, SNPs in genes encoding various signaling components along the PI3K-PTEN-AKT-TSC-mTOR-S6K signaling pathway were found to be associated with colon and rectal cancer risk [70, 71] or disease progression in non-small cell lung cancer (NSCLC) patients treated with platinum compounds [72].