TSPAN8 and neoplasm: In metastatic pancreatic and colorectal carcinoma cell lines, the activation of PKC enhances the colocalization of CO-029 and tetraspanin CD151 with integrin α6β4 in tumor cells, promotes the internalization of this integrin-tetraspanin complex, decreases cell-matrix adhesion on laminin 332, and increases cell migration [18].