They both presented with typical aspects of hypogonadism in which the diagnosis of congenital hypogonadotropic hypogonadism was made given the concomitant very low serum testosterone, low gonadotropin levels and the blunted gonadotropin response (LH and FSH) after GnRH stimulation (Table 1). This evidence concerns the gene PLOD1 and hypogonadotropic hypogonadism.