The proband was screened for mutations in genes known to be associated with CHH including GNRH1, GNRHR1, KISS1, KISS1R, TAC3 and TACR3 and those known to be associated with Kallmann syndrome FGFR1, PROK2 and PROK2R. Analysis of these genes were performed as previously reported [6], [11]–[14]. This evidence concerns the gene KISS1R and cartilage-hair hypoplasia.