In the study by Blows [40], which pooled individual data from more than 10,000 patients with invasive breast cancer from 12 studies with known status of ER, HER2 and at least one basal marker (CK5/6 or EGFR), it was clearly shown that even though for HER2-positive and non-luminal subtypes mortality rates tended to peak within 5 years from diagnosis, with longer follow-up the prognosis became poorer in the luminal subtypes. Here, ESR1 is linked to invasive breast carcinoma.