APP and Alzheimer disease: Of note, consistent findings on greater Aβ burden in females were found in different animal AD models: Tg2576 (APPSWE) mice [19], APP/PS1 [20], APP23 [21], as well as in triple transgenic mice, like 3xTg-AD mice [18, 22] and tripleAD mice ([23], with respect to gender differences: unpublished observations).