SCN5A was expressed at significantly higher levels in BCa (including ductal carcinoma in situ, and invasive, ductal and metastatic BCa), compared with normal breast tissue, in three out of seven datasets for which differential data were available [1.5-fold, P < 0.001, [41] and The Cancer Genome Atlas (TCGA) dataset1; and 3.6-fold, P < 0.05 [42] (Fig. 1a)]. The gene discussed is SCN5A; the disease is ductal breast carcinoma in situ.