Thus, in a work recently published on genetic aberrations in the leukemogenesis of pediatric AML, genes of the HOXB cluster were overexpressed in all patients with a FLT3-ITD positive CN-AML, but not in those with a FLT3-ITD positive and translocation t (15;17)(q21;q22); a finding in agreement with differences in prognostic relevance between these two subgroups [28]. The gene discussed is FLT3; the disease is acute myeloid leukemia.