In multivariate analysis considering known prognostic factors (age, gender, type of leukemia, cytogenetic risk group, WBC, FLT3/ITD, and NPM1 mutant status), EKLF expression (yes/no) remained an independent favorable prognostic factor for EFS (HR 0.4504, 95%CI 0.2115-0.9589, P = 0.038) (Table 4). This evidence concerns the gene FLT3 and leukemia.