Downregulation of GATA1 expression was found in FLT3-ITD AML or AML with cytogenetic abnormalities of chromosome 7, and GATA-2 downregulation was found in AML with chromosome 5, 7 and 11 abnormalities and undifferentiated AML, but the exact underlying mechanisms remain unknown. Here, GATA1 is linked to acute myeloid leukemia.