These have included one case of autoimmune hepatitis in a patient with MS associated with rechallenge of ranitidine [81], new skin lesions in a patient with systemic lupus erythematosus associated with cimetidine [82], lymphocytic infiltration in patients with breast cancer associated with famotidine [83], and exacerbation of psoriasis associated with H2R antagonists [84]. This evidence concerns the gene HRH2 and myeloid sarcoma.