Participant patients with worse metabolic control were younger (mean = 59.15, SD = 4.69 vs. mean = 56.74, SD = 6.26, t = 3.63, P < 0.001), insulin users (43.0% vs. 68.1%, X2 = 16.82, P < 0.001) with higher score on HADS depression (mean = 3.93, SD = 3.11 vs. mean = 4.7, SD = 3.84, t = −2.00, P = 0.047). This evidence concerns the gene INS and depressive disorder.