TP53 and cancer: From the pathway list, we can find that some identified dysregulated pathways involve hallmark cancer genes, such as P53, NF-κB, PI3K, etc. Figure 4 shows the interactions among the five identified dysregulated pathways in PIN, including P53 signaling pathway, JNK MAPK pathway, P38 MAPK pathway, Salmonella pathway, and CDC42RAC pathway, where the last four pathways connect with each other.