KCNN4 and sickle cell disease: However, in a subsequent Phase-3 study, which was designed to compare the rate of acute vasoocclusive pain crisis occurring in sickle cell disease patients, Senicapoc failed to reduce this desired clinical endpoints despite again reducing hemolysis and increasing hemoglobin levels and not inducing any significant adverse events (see [40] for a more extensive discussion of the clinical experiences with KCa3.1 blockers).