RUNX1 and acute myeloid leukemia: Intriguingly, EVI1 overexpression in childhood AML, which has been detected in approximately 10% of cases, is normally not a result of chromosomal rearrangements of the 3q region, but appears to be associated other chromosomal rearrangements and is not of the same prognostic relevance as EVI1 overexpression resulting from chromosomal rearrangements [50].