Endothelial progenitor cells from people with coronary artery disease were found to have slower migration, reduced vascular tube formation, and less effect in restoring circulation in a rodent ischemic limb model, in association with lower SDF-1α-induced phosphorylation of JAK-2, a downstream target of CXCR4 [22]. This evidence concerns the gene JAK2 and coronary artery disorder.