To provide more evidence supporting the role of GFP+LSK− cells in regulating apoptosis of LSCs in CML, we induced CML using the BCR-ABL transduced bone marrow cells from mice lacking the Alox5 gene (Alox5−/−), as in the absence of Alox5, BCR-ABL fails to induce CML due to a functional defect in Alox5−/− LSCs [17]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.