IRF8 and chronic myelogenous leukemia, BCR-ABL1 positive: Lyn-deficient mice display a collection of hematopoietic defects, including autoimmune disease as a result of autoantibody production, and perturbations in myelopoiesis that ultimately lead to splenomegaly and myeloid neoplasia, similar to CML-like disease observed in Icsbp−/− mice [22].