For example, in mice with BCR-ABL induced chronic myeloid leukemia (CML), BCR-ABL-expressing LSK cells function as LSCs [7], and besides BCR-ABL-expressing LSK cells, the bone marrow of CML mice also contains BCR-ABL-expressing LSK− cells [8], [9], although transplantation of cells containing the LSK− cell population does not induce CML in secondary recipient [7]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.