To induce primary CML, we transduced bone marrow cells from wild type (WT) B6 mice with BCR-ABL-GFP retrovirus (GFP serves as an indicator for BCR-ABL expression), followed by transplantation of the transduced cells into lethally irradiated B6 recipient mice [9], [16]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.