High performance of our resequencing approach is also illustrated by the fact that we identified mutations in known candidate drivers in T-ALL that were included in the collection of known cancer genes such as NOTCH1[29], FBXW7[30], PTEN[31], PHF6[14], WT1[32], [33] and PIK3CA[34]. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.