Results showed that BCP double mutation A1762T/G1764A strongly correlated with the occurrence of HCC (OR = 3.98, 95%CI = 3.19–4.95) (See Figure S1); T1753V associated with a 2.23-fold risk (95% CI = 1.69–2.93) (See Figure S2), and C1653T with a 2.55-fold increased risk of HCC (95%CI = 1.95–3.35) (See Table S2, Figure S3). The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.