For example, expression of other actin-related or cytoskeletal proteins has been implicated in schizophrenia and bipolar disorder [33], [51]–[53], and several schizophrenia susceptibility genes interact with actin and the cytoskeleton, including DISC1 [54], calcineurin [55], Akt1 [56] and dysbindin [57]. This evidence concerns the gene DISC1 and bipolar disorder.