SREBF2 and infection: Although the data presented here did not support our second hypothesis that the induction of cellular stress pathways such as the UPR and lipid biosynthesis (e.g., SREBP-2) is necessary for rearrangement and expansion of the ER early after DENV-2 infection, these two hypotheses are not mutually exclusive in that cellular stress pathways do play a role as the infection progresses.