We found no correlation between GTVL and CVL anti-HIV activity in unadjusted analyses or when analyses were adjusted for the PVL, but we did find significant positive correlations between CVL levels of Elafin and SLPI and both the PVL and the GTVL suggesting that some combination of immunodeficiency and mucosal immune activation contribute to the elaboration of innate mucosal defenses. This evidence concerns the gene PI3 and immune system disorder.