CXCR4 and retinal degeneration: In order to extent our in vitro data, we tested in vivo whether CXCR3 and/or CXCR4 were implicated in the regulation of IOP by using highly selective non-peptide antagonists of both chemokine receptors in a rat model of OHT and related retinal degeneration, which was induced by episcleral vein cauterization [29].