Indeed, infection with the virulent strain also led to an increase in expression (1.5 to 2.3 fold) for most of the other pro-inflammatory mediators tested (CCL20, IL-6, IL-12p40, and IFN-γ) as well as to an upregulation (1.7 fold) of the antimicrobial LeukoP as compared to the UI control loops. The gene discussed is IFNG; the disease is infection.