These insights into the function of CLPTM1L, and the fact that copy number gain of the region of chromosome 5p containing CLPTM1L is the most frequent cytogenetic event in the early stages of non-small cell lung cancer (NSCLC) [10] are compelling justification for the study of the role of CLPTM1L in lung cancer as well as other cancer types. The gene discussed is CLPTM1L; the disease is cancer.