SCN5A and familial dilated cardiomyopathy: Since it was first linked to the SCN5A gene in 1996 [14], DCM has been shown to be caused by a number of SCN5A mutations, including two frameshift mutations [15], a deletion mutation [16], and six missense mutations (T220I [17], R225W [18], R814W [15], A1180V [19], D1275N [15], [20], and D1595H [15]).