Compared to the quartile 1 of eGFR, age, the percentage of hypertension and diabetes, the level of SBP, total cholesterol, uric acid, homocysteine, hs-CRP, log NT-proBNP, log hs-cTnT and high predicted Framingham CHD risk score (10-year risk ≥20%) in the quartile 4 of eGFR were higher (P<0.05). This evidence concerns the gene NPPB and diabetes mellitus.