TNF and colitis: Despite the clear involvement of TNFα in regulation of hepcidin expression in DSS colitis and TRUC colitis, we found that neutralization of the cytokine had no effect on hepcidin expression in the spontaneous T cell-mediated intestinal inflammation that occurs in mice with hematopoietic- and endothelial-specific deficiency of the αv integrin [37] (data not shown).