Although the identity and mechanism of action of such factors awaits elucidation, this idea would be consistent with our earlier observations demonstrating increased hepcidin expression in mice with piroxicam/IL-10 knockout colitis and T cell transfer colitis [8], [9], as well as with the results of those studies of human IBD that demonstrate elevated hepcidin levels [5], [6]. Here, HAMP is linked to colitis.