ADH1C and cancer: However, in view of the linkage disequilibrium between ADH1B and ADH1C and the fact that the kinetic differences among ADH1B isozymes are much more striking than those among the ADH1C isozymes [54], some studies ascribed the association between ADH1C polymorphism and cancer risk to the reflects of effect of ADH1B polymorphism, especially in East Asian [18], [32].