In 18 T2DM patients (body mass index (BMI) 30 kg/m2, HbA1c 7.2%, age 59 years) a 12-week combined aerobic and resistance program had no effect on body weight [56] but improved insulin-stimulated glucose disposal and increased IMCLs along with an increase in insulin-stimulated glucose oxidation and suppression of fat oxidation (Table 1). Here, INS is linked to type 2 diabetes mellitus.