First trimester pregnancy and preconceptional risk-factors for GDM have been identified including family history of GDM and/or diabetes [45], maternal pregnancy weight gain [46, 47], fasting plasma glucose [48], 1-hour glucose challenge test [49], oral glucose tolerance test [50], and haemoglobin A1c [51] adiponectin [52, 53], C-reactive protein [54], serum triglycerides [55], sex hormone-binding globulin [56], placental growth factor [57] leptin [58], oxidised DNA [59], and follistatin-like-3 levels [60]. This evidence concerns the gene LEP and gestational diabetes.