Although others have correlated these VEGF SNPs with plasma VEGF levels, due to the lack of available tissue samples, we were unable to correlate VEGF genotype with VEGF mRNA or protein expression within tumors ... Secondly, the sample size of 361 is very large for esophageal cancer but is only average for all studies evaluating VEGF polymorphisms and cancer outcomes (median sample size, 413; range, 100–1193). Here, VEGFA is linked to cancer.